期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 21, 期 1, 页码 61-65出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2009.11.006
关键词
Inflammation; Cancer; Macrophage; Resolution; Anti-inflammatory mechanisms
Inflammation has long been thought to contribute to the development of cancer; however there is also clear evidence that the immune system can recognize and eliminate cancer cells. Current research suggests that cancer-associated inflammation has a dual role in tumor progression; inflammatory mediators promote the malignant activity of cancer cells by acting as growth factors and also stimulate angiogenesis, however, cancer-associated inflammation is also linked with immune-suppression that allows cancer cells to evade detection by the immune system. In this review we will discuss the dual role of inflammation in cancer and how endogenous anti-inflammatory mechanisms may equally be important in carcinogenesis. (C) 2009 Elsevier Ltd. All rights reserved.
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