期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 21, 期 1, 页码 3-10出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2009.11.002
关键词
Lymphocytes; Inflammation; Cancer; Tumors
资金
- Department of Defense Breast Cancer Research
- American Cancer Society
- American Association for Cancer Research
- National Institutes of Health
- Dr. Susan Love Research Foundation
- Department of Defense
The classic view that the role of immune cells in cancer is primarily one of tumor rejection has been supplanted by a more complex view of leukocytes having both pro- and anti-tumor properties. This shift is due to the now well recognized capabilities of several myeloid cell types that foster pro-tumor programming of premalignant tissue, as well as the discovery that subsets of leukocytes also suppress development and effector functions of lymphocytes important for mediating anti-tumor immunity. In this review, we focus on the underappreciated role that T lymphocytes play in promoting tumor development. This includes, in addition to the role of T regulatory cells, a role for natural killer T cells and CD4(+) T helper cells in suppressing anti-tumor immunity and promoting cancer growth and metastasis. (C) 2009 Elsevier Ltd. All rights reserved.
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