期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 20, 期 5-6, 页码 419-427出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2009.10.002
关键词
Mesenchymal stem cell; Pericyte; Therapeutics; Homing; Cell therapy
资金
- Fundacao de Amparo a Pesquisa de Sao Paulo (FAPESP)
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Finaciadora de Estudos e Projetos (FINEP)
- National Institutes of Health (NIH)
Mesenchymal stem cells (MSCs) have been described as being able to give rise to several quite different mesenchymal cell phenotypes. However, the ability to differentiate is not the only characteristic that makes these cells attractive for therapeutic purposes. The secretion of a broad range of bioactive molecules by MSCs, such as growth factors, cytokines and chemokines, constitutes their most biologically significant role under injury conditions. Understanding this intricate secretory activity as well as the properties of MSCs in vivo is central to harnessing their clinical potential. Herein, we identify some of the molecules involved in the paracrine effects of MSCs with a perspective that these cells intrinsically belong to a perivascular niche in vivo, and discuss how this knowledge could be advantageously used in clinical applications. (C) 2009 Elsevier Ltd. All rights reserved.
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