期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 20, 期 5-6, 页码 435-440出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2009.10.012
关键词
Dental pulp stem cells; Side population cells; CD31; CD105; Pulp regeneration; Angiogenesis; Neurogenesis; Amputated pulp; Dentinogenesis
资金
- Japan Science and Technology Agency
- Ministry of Education, Science, Sports and Culture, Japan [19659499, 20390504, 19791418]
- Research Grants for Longevity Sciences [19C-2, 21A-7]
Dental caries is a common public health problem, causing early loss of dental pulp and resultant tooth loss. Dental pulp has important functions to sustain teeth providing nutrient and oxygen supply, innervation, reactionary/reparative dentin formation and immune response. Regeneration of pulp is an unmet need in endodontic therapy, and angiogenesis/vasculogenesis and neurogenesis are critical for pulp regeneration. Permanent and deciduous pulp tissue is easily available from teeth after extraction without ethical issues and has potential for clinical use. In this review, we introduce some stem cell subfractions, CD31(-)/CD146(-) SP cells and CD105(+) cells with high angiogenic and neurogenic potential, derived from human adult dental pulp tissue. Potential utility of these cells is addressed as a source of cells for treatment of cerebral and limb ischemia and pulp inflammation complete with angiogenesis and vasculogenesis. (C) 2009 Elsevier Ltd. All rights reserved.
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