期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 20, 期 5-6, 页码 441-448出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2009.10.020
关键词
Bone marrow-mesenchymal cells (BMSC); Bone morphogenetic protein-6 (BMP-6); Bmp-/- mouse; Iron metabolism; Glucose regulation; Diabetes; Bone formation; Coupling of bone formation to resorption; Macrophage; Synovial cells; Cartilage repair; Osteogenic transcription factors; BMP-6 receptors; BMP-6 structure
Bone morphogenetic protein-6 (BMP-6) is produced by bone marrow-mesenchymal (BMSC) and hematopoietic stem cells, which can differentiate into bone, cartilage, adipose, muscle, hematopoietic, synovial and other tissues. Bmp6-/- null mice have low hepcidin serum levels and an iron overload, resembling hereditary hemochromatosis, which may cause a reduced number of pancreatic P-cells, increased serum glucose and diabetes. BMP-6 circulates in the normal human plasma and is produced by BMSC prior to differentiation into osteoblasts. Moreover, it is also released by osteoclasts as a key bone coupling factor recruiting osteoblasts to the resorption site. Due to unique structural, receptor binding and signaling characteristics much smaller amounts of BMP-6 than BMP-7 are needed in vivo to induce regeneration of bone defects in animals. (C) 2009 Elsevier Ltd. All rights reserved.
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