期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 20, 期 1, 页码 43-59出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2008.11.006
关键词
Cytokines; Single nucleotide polymorphisms; Genetic polymorphism
资金
- British Heart Foundation [RG/08/008/25291] Funding Source: Medline
- British Heart Foundation [RG/08/008/25291] Funding Source: researchfish
Cytokines, signaling proteins produced by a variety of cell types, are essential for the development and functioning of both innate and adaptive immune response. Cytokine gene expression is tightly regulated, and aberrant expression from environmental and genetic polymorphism. has been implicated in a range of diseases, susceptibility to infections, and responses to treatment. This review concentrates on the functionality of cytokine and cytokine receptor gene polymorphisms; it is through these variants that genuine disease-associations are based. Several mechanisms for single nucleotide polymorphism (SNP) functionality are present within cytokine genes including: amino acid changes (IL-6R, IL-13, IL-1 alpha), exon skipping (IL-7R alpha), proximal promoter variants (IL-1 beta, IL-Ra, IL-2, IL-6, IL-10, IL-12, IL-13, IL-16, TNF, IFN-gamma, TGF-beta), distal promoter variants (IL-6, IL-18) and intronic enhancer variants (IL-8). (C) 2008 Elsevier Ltd. All fights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据