期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 20, 期 5-6, 页码 517-521出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2009.10.004
关键词
TGF beta; BMP; Smad; miRNA; Drosha; Processing; Pri-miRNA; Pre-miRNA
资金
- National Institute of Health [HL082854, HL093154]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL093154, R01HL082854] Funding Source: NIH RePORTER
microRNAs (miRNAs) are small, non-coding RNAs that modulate diverse biological functions through the repression of target genes. miRNA profiling studies have indicated that the levels of miRNAs are altered during normal development and pathogenesis of various diseases, including cancer and cardiovascular disorders. The signaling pathways which control miRNA biogenesis and the mechanisms of regulation, however, are not well understood. Following transcription, mature miRNAs are generated through a series of coordinated processing events mediated by large protein complexes. We recently found that signal transducers of the Transforming Growth Factor beta (TGF beta) signaling pathway, the Smads, play a regulatory role in the processing of miRNA in the nucleus. In this review, we summarize the current understanding of the regulation of miRNA biogenesis mediated by the TGF beta signaling pathway. (C) 2009 Elsevier Ltd. All rights reserved.
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