期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 20, 期 3, 页码 203-212出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2009.05.001
关键词
BMP; Receptors; Angiogenesis; HHT; PAH
资金
- INSERM
- CEA
- ARC
Bone morphogenetic proteins (BMPs) are Multifunctional growth factors belonging to the transforming growth factor beta (TGF beta) superfamily. Recent observations clearly emphasize the emerging role of BMPs in angiogenesis: (i) two genetic vascular diseases (hereditary hemorrhagic telangiectasia (HHT) and pulmonary arterial hypertension (PAH)) are caused by mutations in genes encoding components of the BMP signalling pathway (endoglin, ALK1 and BMPRII). (ii) BMP9 has been identified as the physiological ligand of the endothelial receptor ALK1 in association with BMPRII. This review will focus on the diverse functions of BMPs in angiogenesis. We will propose a model that distinguishes the BMP2, BMP7 and GDF5 subgroups from the BMP9 subgroup on the basis of their functional implication in the two phases of angiogenesis (activation and maturation). (C) 2009 Elsevier Ltd. All rights reserved.
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