期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 20, 期 5-6, 页码 389-398出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2009.10.008
关键词
BMP; Receptors; RGM; DRAGON; HJV
资金
- Massachusetts Biomedical Research Council
- MGH Executive Committee on Research
- Associazione Modenese per le Malattie del Fegato
- National Institutes of Health [K08 DK-075846, RO1 DK-069533, RO1 DK-071837]
- National Kidney Foundation
- Massachusetts General Hospital
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK071837, K08DK075846, R01DK069533] Funding Source: NIH RePORTER
The BMP signaling pathway controls a number of cell processes during development and in adult tissues. At the cellular level, ligands of the BMP family act by binding a hetero-tetrameric signaling complex, composed of two type I and two type If receptors. BMP ligands make use of a limited number of receptors, which in turn activate a common signal transduction cascade at the intracellular level. A complex regulatory network is required in order to activate the signaling cascade at proper times and locations, and to generate specific downstream effects in the appropriate cellular context. One such regulatory mechanism is the repulsive guidance molecule (RGM) family of BMP co-receptors. This article reviews the current knowledge regarding the structure, regulation, and function of RGMs, focusing on known and potential roles of RGMs in physiology and pathophysiology. (C) 2009 Elsevier Ltd. All rights reserved.
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