期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 20, 期 2, 页码 153-164出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2009.02.007
关键词
Activin; Inflammation; Follistatin; Circulation
资金
- National Health and Medical Research Council of Australia
Activin A, a member of the transforming growth factor-beta superfamily, is released rapidly into the circulation during inflammation. This review examines the evidence that activin is a critical mediator of inflammation and immunity. Activin modulates several aspects of the inflammatory response, including release of pro-inflammatory cytokines, nitric oxide production and immune cell activity. Crucially, inhibiting activin with follistatin, a high affinity binding protein, alters the pattern of cytokines released and improves survival in a mouse model of endotoxic shock. Serum and tissue concentrations of activin are elevated in a wide range of pathological conditions. The utility of activin as a diagnostic marker of clinical inflammation and the use of follistatin to block activin actions therapeutically are also discussed. (C) 2009 Elsevier Ltd. All rights reserved.
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