期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 19, 期 3-4, 页码 231-244出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2008.04.010
关键词
knockout; transgenic mice; disease models; anti-cytokine therapy
资金
- Howard Hughes Medical Institute Funding Source: Medline
TNF is an exciting cytokine which has helped to establish many paradigms in immunology. Although TNF itself has found only very limited use in the clinic, anti-cytokine therapy, which targets this single molecule, has enjoyed astounding success in treatment of a growing number of human diseases. However, since TNF mediates unique physiologic functions, in particular those related to host defense, TNF blockade may result in unwanted consequences. Much of our understanding about TNF intrinsic functions in the body, as well as about consequences of its overexpression and ablation, is based on studying phenotypes of various genetically engineered mice. Here we review mouse studies aimed at understanding TNF physiologic functions using transgenic and knockout models, and we discuss additional mouse models that may be helpful in the future. (c) 2008 Elsevier Ltd. All rights reserved.
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