期刊
CYTOKINE & GROWTH FACTOR REVIEWS
卷 19, 期 5-6, 页码 405-413出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.cytogfr.2008.08.002
关键词
TGF-beta; Chagas disease; Trypanosoma cruzi; Cardiac fibrosis
资金
- Conselho Nacional de Desenvolvimento Cientffico e Tecnologico (CNPq)
- Oswaldo Cruz Foundation (Fiocruz)
- Funclaqdo Carlos Chagas Filho de Amparo Pesquisa do Estado do Rio de Janeiro (Faperj) (Brazil)
- Commissariat h I'Energie Atomique (Direction des Sciences du Vivant)
- Institut National de la Sante et de la Recherche Medicale (Inserm), (France)
This paper summarizes recent data from the literature suggesting that transforming growth factor-P (TGF-beta) participates at least in four different processes influencing development of myocardiopathy in Chagas disease, a major parasitic illness caused by Trypanosoma cruzi infection: (a) invasion of cardiac fibroblasts and myocytes; (b) intracellular parasite cycle; (c) regulation of inflammation and immune response; (d) fibrosis and heart remodeling during acute and chronic disease. All these effects point to an important role of TGF-beta in Chagas 7 disease myocardiopathy and suggest that monitoring the circulating levels of this cytokine could be of help in clinical prognosis and management of patients. Moreover, TGF-beta-interfering therapies appear as interesting adjuvant interventions during acute and chronic phases of T cruzi infection. (c) 2008 Elsevier Ltd. All rights reserved.
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