期刊
CYTOKINE
卷 60, 期 1, 页码 1-12出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2012.06.018
关键词
MCP-1; Inflammation; Obesity; Diabetes; Diabetic complications
资金
- NCCAM [R21 AT003874]
- ORWH [R21 AT005139]
- RCMI/BRIDGES [5G12RR003061]
- RTRN [1J54RR022762]
- NCRR [5P2ORR016467]
monocyte Chemoattractant Protein-1 (MCP-1) is the first discovered and most extensively studied CC chemokine, and the amount of studies on its role in the etiologies of obesity- and diabetes-related diseases have increased exponentially during the past two decades. This review attempted to provide a panoramic perspective of the history, regulatory mechanisms, functions, and therapeutic strategies of this chemokine. The highlights of this review include the roles of MCP-1 in the development of obesity, diabetes, cardiovascular diseases, insulitis, diabetic nephropathy, and diabetic retinopathy. Therapies that specifically or non-specifically inhibit MCP-1 overproduction have been summarized. (C) 2012 Elsevier Ltd. All rights reserved.
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