期刊
CYTOKINE
卷 59, 期 2, 页码 313-316出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2012.04.024
关键词
Pen-implant sulcus fluid; OPG; RANKL; IL-1 beta; IL-10
资金
- Hacettepe University Research Foundation [09 D05 201 002 (4886)]
Objectives: Since ingredients of pen-implant sulcus fluid (PISF) may be related to the bony structure surrounding dental implants, analyze of specific markers related to bone resorption in PISF seems to be suitable for long term monitoring of pen-implant health. It is suggested that analysis of PISF may serve for detection of inflammation. The aim of this study is to analyze PISF interleukin-1 beta (IL-1 beta), IL-10, osteoprotegerin (OPG), receptor activator of nuclear factor-kappa B ligand (RANKL) levels to determine whether the diagnostic value of PISF can be used to evaluate early changes around implants. Materials and methods: A total of 47 dental implants either healthy/non-inflamed (n = 20) (Group I), or gingivitis/inflamed (n = 27) (Group II), were classified. Pen-implant status has been evaluated by clinical evaluation (plaque index, gingival index, probing depth and gingival bleeding time index) were recorded and PISF samples were also obtained. PISF IL-1 beta, IL-10, RANKL, and OPG levels were measured by enzyme-linked immunosorbent assay. Potential volumetric changes in PISF were also evaluated. Results: All clinical parameters and volume of PISF were higher in Group II and these differences were statistically significant except volume values. IL-1 beta, IL-10 and OPG levels in PISF were significantly higher in Group II. Although the PISF RANKL level in Group II was higher than the level of Group I, the difference between groups did not reach the statistically significant level. Conclusions: These data suggest that a balance of inflammatory- and osteoclastogenesis related molecules locally produced may play an important role in the development of inflammatory pen-implant lesions. (C) 2012 Elsevier Ltd. All rights reserved.
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