期刊
CYTOKINE
卷 56, 期 3, 页码 621-626出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2011.08.028
关键词
Inflammation; Premature infant; Longitudinal study; Supplemental oxygen; Cytokines
资金
- Molly Towell Perinatal Research Foundation
- Division of Neonatology
- Child & Family Research Award
- Canadian Child Health Clinician Scientist Program
- Sick Kids Foundation
- Child & Family Research Institute
- Women & Children's Health Research Institute (Alberta)
- Manitoba Institute of Child Health
Background: Systemic inflammation, typically attributed to sepsis, has been repeatedly linked to adverse long-term outcomes in infants born prematurely. However, it is unclear whether other factors can contribute to potentially harmful systemic inflammatory responses. Objective: To determine the timing and extent of systemic inflammation occurring in absence of infection in preterm infants exposed to intensive care. Methods: First, we screened for inflammation biomarkers most strongly linked to infection in a large prospective cohort of 425 newborns (gestational age 24-42 weeks). Second, we longitudinally measured levels of infection-related inflammation biomarkers up to 42 days of post-natal life in a series of 58 infants born <= 30 weeks of gestation exposed to intensive care. Ante- or post-natal infections were excluded using stringent definitions including rigorous histological placental examination. Spearman correlations were used to identify putative clinical factors potentially linked to inflammation. Results: Three biomarkers were most strongly associated with neonatal sepsis (IL-6, IL-8 and G-CSF) in the first cohort. Using these markers, we found a predominant early high intensity systemic inflammation period within the first 72 h of preterm infants' extra-uterine life. Remarkably, this systemic inflammatory response was of magnitude comparable to that observed during sepsis in absence of ante- or post-natal signs of infection, and correlated with the amount of supplemental oxygen exposure (r = 0.51-0.60). Conclusions: Non-infectious sources of systemic inflammation are significant in preterm infants exposed to intensive care and may contribute to intensive care-related organ injury. (C) 2011 Elsevier Ltd. All rights reserved.
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