期刊
CYTOKINE
卷 51, 期 2, 页码 144-150出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2010.04.012
关键词
Interleukin-10; Prolactin receptor; Peripheral blood mononuclear cells; Breast cancer
资金
- University Grants Commission, New Delhi [F.2.77/98]
- Council of Scientific and Industrial Research, New Delhi [9/482(0049)/2009-EMR-I]
- Council of Scientific and Industrial Research [9/945/(0001)/2005-EMR-I, 9/482(0037)/2004-EMR-I]
Peripheral blood mononuclear cells (PBMC) of breast cancer patients show altered prolactin (PRL)-induced proinflammatory response and express short form of prolactin receptor (PRL-R), besides secreting elevated level of interleukin (IL)-10 than that of the normal counterparts. IL-10 depleted the functional long form of PRL-R mRNA and protein, expressed PRL-R (SF) mRNA and blocked the PRL response found in normal individuals, which could be a mechanism to suppress the proinflammatory immune responses during malignancy. (C) 2010 Elsevier Ltd. All rights reserved.
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