期刊
CYTOKINE
卷 45, 期 2, 页码 58-69出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.cyto.2008.11.010
关键词
miRNA; ARE; Cytokine; Chemokine; Evolution
资金
- NIH [HD 17013, CA 124971]
In this review we discuss specific examples of regulation of cytokine genes and focus on a new mechanism involving post-transcriptional regulation via miRNAs. The post-transcriptional regulation of cytokine genes via the destabilizing activity of AU-rich elements [AREs] and miRNAs is a pre-requisite for regulating the half-life of many cytokines and achieving the temporal and spatial distributions required for regulation of these genes. (C) 2008 Elsevier Ltd. All rights reserved.
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