期刊
CYTOGENETIC AND GENOME RESEARCH
卷 143, 期 1-3, 页码 144-149出版社
KARGER
DOI: 10.1159/000360435
关键词
Cell cycle; Centromere identity; Histone phosphorylation
资金
- National Natural Science Foundation of China [31130033, 31071083, 31320103912]
- NSF [DBI 0922703, DBI 0701297]
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [0922703] Funding Source: National Science Foundation
As the main protein components of chromatin, histones can alter the structural/functional capabilities of chromatin by undergoing extensive post-translational modifications (PTMs) such as phosphorylation, methylation, acetylation, ubiquitination, sumoylation, and so on. These PTMs are thought to transmit signals from the chromatin to the cell machinery to regulate various processes. Histone phosphorylation is associated with chromosome condensation/segregation, activation of transcription, and DNA damage repair. In this review, we focus on how different histone phosphorylations mark for chromatin change during the cell cycle, the relationship between histone phosphorylation and functional centromeres, and the candidate kinases that trigger and the phosphatase or kinase inhibitors that alter histone phosphorylation. Finally, we review the crosstalk between different PTMs. (C) 2014 S. Karger AG, Basel
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