期刊
CYTOGENETIC AND GENOME RESEARCH
卷 139, 期 3, 页码 164-173出版社
KARGER
DOI: 10.1159/000348679
关键词
Cancer evolution; Cell death heterogeneity; Chromosome fragmentation; Genome chaos; Genome theory; Mitotic cell death; Non-clonal chromosomal aberration
资金
- DOD [GW093028]
- Susan G. Komen Breast Cancer Foundation
- National CFIDS Foundation
- Nancy Taylor Foundation for Chronic Diseases
- SeeDNA Biotech Inc.
Cell death constitutes a number of heterogeneous processes. Despite the dynamic nature of cell death, studies of cell death have primarily focused on apoptosis, and cell death has often been viewed as static events occurring in linear pathways. In this article we review cell death heterogeneity with specific focus on 4 aspects of cell death: the type of cell death; how it is induced; its mechanism(s); the results of cell death, and the implications of cell death heterogeneity for both basic and clinical research. This specifically reveals that cell death occurs in multiple overlapping forms that simultaneously occur within a population. Network and pathway heterogeneity in cell death is also discussed. Failure to integrate cell death heterogeneity within analyses can lead to inaccurate predictions of the amount of cell death that takes place in a tumor. Similarly, many molecular methods employed in cell death studies homogenize a population removing heterogeneity between individual cells and can be deceiving. Finally, and most importantly, cell death heterogeneity is linked to the formation of new genome systems through induction of aneuploidy and genome chaos (rapid genome reorganization). Copyright (C) 2013 S. Karger AG, Basel
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据