期刊
CURRENT VASCULAR PHARMACOLOGY
卷 8, 期 2, 页码 233-248出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157016110790886983
关键词
Innate immunity; inflammation; macrophage; activation; M1 M2; polarization
资金
- Netherlands Heart Foundation [2005B175, 2007T067]
- Netherlands Organisation for Scientific Research [Vidi 016-066-329]
- European Union [MEST-CT-2005-020706/CADRE2]
- Netherlands Heart Foundation
Atherosclerosis is a chronic inflammatory disease involving many cell types with a well-accepted key role for macrophages. A wide array of different properties and functional characteristics are attributed to macrophages present in the atherosclerotic plaque. As an increasing body of evidence strengthens the consensus that macrophages comprise a heterogeneous population, several co-existing subtypes with diverse, even opposing specialties have already been described in fields like parasitology, tumour biology and metabolic disorders. However, macrophage heterogeneity within atherosclerotic lesions has not been studied in detail yet. In this review we will introduce the characteristics of macrophage subsets in other pathologies and address the presence and possible roles of distinct macrophage subtypes in the rapidly evolving field of atherosclerosis. Finally, we make an effort to relate these subtypes to disease progression and explore a number of opportunities for novel diagnostic and therapeutic approaches.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据