期刊
CURRENT TOPICS IN MEDICINAL CHEMISTRY
卷 14, 期 3, 页码 340-342出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026613666131127160819
关键词
Open access chemical biology; kinase inhibitor probe
To catalyze research on historically untargeted protein kinases, we created the PKIS, an annotated set of 367 small molecule kinase inhibitors. The set has been widely distributed to academic collaborators as an open access tool. It has been used to identify chemical starting points for development of chemical probes for orphan kinases and to investigate kinase signaling in high content phenotypic assays. Access to the set comes with few restrictions other than the requirement that assay results be released into the public domain for the benefit of the entire research community. Examples from the efforts of several collaborators are summarized.
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