期刊
CURRENT TOPICS IN MEDICINAL CHEMISTRY
卷 12, 期 2, 页码 108-119出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156802612798919123
关键词
siRNA; delivery; polymers; RNA interference; polyplexes; endosomal escape; in vivo; safety
资金
- Technology Foundation STW of The Netherlands Organization for Scientific Research NWO [7468]
RNA interference is a technique to induce sequence-specific gene silencing, but is hampered by inefficient delivery of its mediator, short interfering RNA, into target cells. This review describes recent advances in siRNA delivery using polymeric carrier systems. Structural variations that have been applied to these polymers for optimizing their intracellular trafficking are discussed, as well as strategies for stabilization and targeting to diseased tissues in vivo. Recent findings have highlighted safety issues that need to be taken into account in the design of nanoparticles for clinical application.
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