期刊
CURRENT TOPICS IN MEDICINAL CHEMISTRY
卷 12, 期 21, 页码 2393-2403出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156802612805289953
关键词
Endophenotype; intermediate phenotype; structural connectivity; functional connectivity; schizophrenia
资金
- NIMH [K08 MH068540]
- National Association for Research in Schizophrenia and Affective Disorders (NARSAD) through the Blowitz-Ridgeway Foundation
- National Association for Research in Schizophrenia and Affective Disorders (NARSAD) through NWO ZonMw TOP [91211021]
- Gralnick Prize for Severe Mental Illness from the American Psychological Foundation
- Lieber Prize for Outstanding Schizophrenia Research from NARSAD
The tremendous heterogeneity in the clinical symptoms and cognitive/emotional deficits seen in patients with schizophrenia has made it challenging to determine the underlying pathogenesis of the illness. One leading hypothesis that has come to the forefront over the past several decades is that schizophrenia is caused by aberrant connectivity between brain regions. In fact, a new field of connectomics has emerged to study the effects of brain connectivity in health and illness. It is known that schizophrenia is highly heritable, although in the search for the underlying genetic factors we have only scratched the tips of the omics icebergs. One technique to help identify underlying genetic factors is the use of heritable intermediate phenotypes, or endophenotypes. Endophenotypes provide mechanisms to study the genetic underpinnings of the disorder by focusing on measureable traits that are more proximal to gene regulation and expression than are symptoms. Thus, the goal of this paper is to conduct a critical review of the evidence linking both structural and functional connectivity as an endophenotype for schizophrenia.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据