期刊
CURRENT TOPICS IN MEDICINAL CHEMISTRY
卷 10, 期 17, 页码 1785-1791出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156802610792928095
关键词
Multidrug transporters; antiepileptic drugs; brain imaging; positron emission tomography; verapamil; tariquidar
资金
- Deutsche Forschungsgemeinschaft (Bonn, Germany) [Lo 274/9]
- National Institutes of Health [R21 NS049592]
- European Community [201380]
- Austrian Science Fund (FWF) [SFB F35]
The issue of pharmacoresistance in epilepsy has received considerable attention in recent years, and a number of plausible hypotheses have been proposed. Of these, the so-called transporter hypothesis is the most extensively researched and documented. This hypothesis assumes that refractory epilepsy is associated with a localised over-expression of drug transporter proteins such as P-glycoprotein (Pgp) in the region of the epileptic focus, which actively extrudes antiepileptic drugs (AEDs) from their intended site of action. However, although this hypothesis has biological plausibility, there is no clinical evidence to support the assertion that AEDs are sufficiently strong substrates for transporter-mediated extrusion from the brain. The use of modern brain imaging techniques to determine Pgp function in patients with refractory epilepsy has started only recently, and may ultimately determine whether increased expression and function of Pgp or other efflux transporters are involved in AED resistance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据