期刊
CURRENT TOPICS IN MEDICINAL CHEMISTRY
卷 9, 期 11, 页码 1038-1048出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156802609789630974
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The p38 kinase plays a central role in inflammation, and it has been the subject of extensive efforts in both basic research and drug discovery. This review summarizes the biology of the p38 kinase with a focus on its role in inflammation. The p38 kinase regulates the production of key inflammatory mediators by cells of the innate immune system, including TNF alpha, IL-1 beta and COX-2. In addition, p38 also acts downstream of cytokines such as TNF alpha, mediating some of their effects. Recently p38 has also been found to play a role in responses of T cells, including Th17 and regulatory T cells. Consistent with its important role in inflammation, recent evidence suggests cells may utilize a variety of feedback mechanisms to regulate and maintain p38 signal transduction. The biological processes regulated by p38 kinase suggest both a wide variety of potential indications for inhibitors and a level of complexity that has proven challenging to drug discovery efforts around this target.
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