期刊
CURRENT TOPICS IN MEDICINAL CHEMISTRY
卷 9, 期 1, 页码 13-33出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156802609787354333
关键词
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Glycosidases mediate the digestion of oligosaccharides in the small intestine as well as the processing of cell surface oligosaccharides, which play important roles in cell to cell recognition during infections, metastasis, and immune responses. Thus, agents that control the activities of glycosidases could have therapeutic effects against many carbohydrate-related diseases. In fact, many fruitful efforts have been made to design and synthesize glycosidase inhibitors as clinically practical medicines. This review summarizes the current stage of development of such inhibitors to treat diabetes, influenza, virus infection of HIV, tumor metastasis, and glycosyl sphingo lipid (GSL) storage diseases.
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