期刊
CURRENT TOPICS IN MEDICINAL CHEMISTRY
卷 9, 期 4, 页码 322-329出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156802609788317874
关键词
Cancer chemotherapy; K-v; K-Ca; K-ir; K-2P; K+ channel modulators; mechanisms of action
资金
- National 863 Program [2007AA02Z307]
- Innovation Program for the Postgraduates in Jiangsu
As trans-membrane proteins located in cytoplasm and organelle membrane, potassium (K+) channels are generally divided into four super-families: voltage-gated K+ channels (K-v), Ca2+-activated K+ channels (K-Ca), inwardly rectifying K+ channels (K-ir) and two-pore domain K+ channels (K-2P). Since dysfunctions of K+ channels would induce many diseases, various studies toward their functions in physiologic and pathologic process have been extensively launched. This review focuses on the recent advances of K+ channels in tumor progression, including the brief introduction of K+ channels, the role of K+ channels in tumor cells, the possible mechanism of action at cellular level, and the possible application of K+ channel modulators in cancer chemotherapy.
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