期刊
CURRENT TOPICS IN MEDICINAL CHEMISTRY
卷 8, 期 6, 页码 448-459出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156802608783955656
关键词
anticancer antibiotic; biosynthesis; C-1027; enediynes; maduropeptin; neocarzinostatin; polyketide synthase
资金
- NATIONAL CANCER INSTITUTE [R01CA078747] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [K02AI051689] Funding Source: NIH RePORTER
- NCI NIH HHS [R01 CA078747-09, R01 CA078747, F32 CA105984] Funding Source: Medline
- NIAID NIH HHS [K02 AI051689] Funding Source: Medline
The enediyne polyketides are secondary metabolites isolated from a variety of Actinomycetes. All members share very potent anticancer and antibiotic activity, and prospects for the clinical application of the enediynes has been validated with the recent marketing of two enediyne derivatives as anticancer agents. The biosynthesis of these compounds is of interest because of the numerous structural features that are unique to the enediyne family. The gene cluster for five enediynes has now been cloned and sequenced, providing the foundation to understand natures' means to biosynthesize such complex, exotic molecules. Presented here is a review of the current progress in delineating the biosynthesis of the enediynes with an emphasis on the model enediyne, C-1027.
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