期刊
CURRENT TOPICS IN MEDICINAL CHEMISTRY
卷 8, 期 14, 页码 1165-1179出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/156802608785849049
关键词
PAMAM dendrimer; drug delivery; cancer diagnosis; cancer therapy; chemotherapy; photodynamic therapy; MRI; apoptosis
资金
- National Cancer Institute
- National Institutes of Health [1 R01 CA119409, NO1-CO-27173]
- Michigan Economic Development Corporation-Life Sciences Corridor Fund
In recent years, medicinal chemists have begun to realize that dendrimers may be a keystone in the future of medicine. The field of oncology will soon be revolutionized by novel strategies for diagnosis and therapy employing dendrimer-based nanodevices. In the near future, cancer diagnosis via MRI will be improved by the incorporation of dendrimers as advanced contrast agents. Novel dendrimer-based contrast agents can not only be targeted specifically to cancer cells but may also incorporate a cytotoxic function to induce apoptosis on said cells as well. Dendrimers are being applied to a variety of cancer therapies to improve the safety and effectiveness of many common therapeutics. Investigations into the applicability of dendrimers in photodynamic therapy, boron neutron capture therapy, and gene transfection are also being undertaken. This review will cover the fundamentals of cutting-edge research utilizing dendrimers for cancer diagnosis and therapy. An objective review of these new technologies will detail how dendrimer-based nanodevices are advantageous over conventional medicine.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据