期刊
JOURNAL OF NEUROVIROLOGY
卷 22, 期 1, 页码 14-21出版社
SPRINGER
DOI: 10.1007/s13365-015-0355-x
关键词
Host behaviour; Parasite; Commensal; Epigenetics; Metagenome; Host ecology; Neurovirus; Co-evolution
Research on the microbiome and its interaction with various host organs, including the brain, is increasingly gaining momentum. With more evidence establishing a comprehensive microbiota-gut-brain axis, questions have been raised as to the extent to which microbes influence brain physiology and behaviour. In parallel, there is a growing literature showing active behavioural manipulation in favour of the microbe for certain parasites. However, it seems unclear where the hidden majority of microbes are localised on the parasitism-mutualism spectrum. A long evolutionary history intimately connects host and microbiota, which complicates this classification. In this conceptual minireview, we discuss current hypotheses on host-microbe interaction and argue that novel experimental approaches and theoretical concepts, such as the hologenome theory, are necessary to incorporate transgenerational epigenetic inheritance of the microbiome into evolutionary theories.
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