期刊
CURRENT PROTEIN & PEPTIDE SCIENCE
卷 13, 期 8, 页码 699-722出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920312804871193
关键词
antibiotics; bacterial multidrug resistance; bacteriophage therapy; phage-encoded proteins application
The emergence of bacteria resistance to most of the currently available antibiotics has become a critical therapeutic problem. The bacteria causing both hospital and community-acquired infections are most often multidrug resistant. In view of the alarming level of antibiotic resistance between bacterial species and difficulties with treatment, alternative or supportive antibacterial cure has to be developed. The presented review focuses on the major characteristics of bacteriophages and phage-encoded proteins affecting their usefulness as antimicrobial agents. We discuss several issues such as mode of action, pharmacodynamics, pharmacokinetics, resistance and manufacturing aspects of bacteriophages and phage-encoded proteins application.
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