期刊
CURRENT PROTEIN & PEPTIDE SCIENCE
卷 13, 期 5, 页码 490-500出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920312802430554
关键词
aminopeptidase A; aminopeptidase B; aminopeptidase N; renin-angiotensin system; hypertension; angiogenesis; metastasis
Various aminopeptidases belong to the M1 aminopeptidase family. They are all zinc dependent enzymes playing important roles in several biological processes such as regulation of blood pressure under both physiological and pathological conditions, and the angiogenesis and metastasis of tumor, etc. They all have the highly conserved HEXXH(X)(18)E zinc-binding and GAMEN motifs essential for enzyme activities. In this review, the current situation regarding the biochemical characteristics, biological functions and inhibitors of three important members of these enzymes, aminopeptidase A, aminopeptidase N and aminopeptidase B are summarized.
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