期刊
CURRENT PROTEIN & PEPTIDE SCIENCE
卷 12, 期 6, 页码 520-530出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920311796957612
关键词
3D Zernike descriptor; protein surface comparison; ligand binding site comparison; protein docking prediction
资金
- National Institute of General Medical Sciences of the National Institutes of Health [R01GM075004]
- NSF [DMS0800568, EF0850009, IIS0915801]
The tertiary structures of proteins have been solved in an increasing pace in recent years. To capitalize the enormous efforts paid for accumulating the structure data, efficient and effective computational methods need to be developed for comparing, searching, and investigating interactions of protein structures. We introduce the 3D Zernike descriptor (3DZD), an emerging technique to describe molecular surfaces. The 3DZD is a series expansion of mathematical three-dimensional function, and thus a tertiary structure is represented compactly by a vector of coefficients of terms in the series. A strong advantage of the 3DZD is that it is invariant to rotation of target object to be represented. These two characteristics of the 3DZD allow rapid comparison of surface shapes, which is sufficient for real-time structure database screening. In this article, we review various applications of the 3DZD, which have been recently proposed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据