期刊
CURRENT PROTEIN & PEPTIDE SCIENCE
卷 11, 期 6, 页码 485-496出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920310791824138
关键词
Phosphorylation; post-translational modification; kinase-specific; phospho-binding motif; phosphorylation network
资金
- National Basic Research Program [2006CB933300, 2007CB947401, 2010CB945400]
- National Natural Science Foundation of China [90919001, 30700138, 30830036, 30900835]
- Chinese Academy of Sciences [KSCX2-YW-R-139, INFO-115-C01-SDB4-36]
- National Science Foundation for Post-doctoral Scientists [20080430100]
Protein phosphorylation is the most ubiquitous post-translational modification (PTM), and plays important roles in most of biological processes. Identification of site-specific phosphorylated substrates is fundamental for understanding the molecular mechanisms of phosphorylation. Besides experimental approaches, prediction of potential candidates with computational methods has also attracted great attention for its convenience, fast-speed and low-cost. In this review, we present a comprehensive but brief summarization of computational resources of protein phosphorylation, including phosphorylation databases, prediction of non-specific or organism-specific phosphorylation sites, prediction of kinase-specific phosphorylation sites or phospho-binding motifs, and other tools. The latest compendium of computational resources for protein phosphorylation is available at: http://gps.biocuckoo.org/links.php
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