期刊
CURRENT PROTEIN & PEPTIDE SCIENCE
卷 10, 期 4, 页码 388-394出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920309788922216
关键词
GADD45 alpha; Stress; Tumor suppressor; Tumor progression
资金
- National Natural Science Foundation of China [30871277]
- Beijing Natural Science Foundation [5092022]
Mammalian cells are prone to tumorigenesis when suffering the genotoxic stresses, and the existence of the tumor suppressors validly decrease this possibility. Gadd45 alpha is one of the growth arrest and DNA damage-inducible (Gadd) 45 gene family members and serves as a stress sensor and tumor suppressor under most stress conditions, which is evidenced by cell cycle arrest, DNA repair, senescence or apoptosis triggered by induction of GADD45 alpha expression. However, some recent reports have challenged this notion by demonstrating the correlation of GADD45 alpha expression to cell survival and even progression of certain tumor cells. Therefore, GADD45 alpha seems to exert multiple roles in stress signaling and tumor development. Elucidation of the related mechanisms will be helpful for the establishment of novel tumor therapeutic strategy targeting GADD45 alpha.
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