期刊
CURRENT PROTEIN & PEPTIDE SCIENCE
卷 9, 期 6, 页码 578-590出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920308786733895
关键词
hemoglobin; polar fish; evolution; Root effect; X-ray structure
资金
- Italian National Programme for Antarctic Research (PNRA)
- Italian National Research Council
- SCAR programme Evolution of Antarctic Organisms (EVOLANTA)
- TUNU I
- TUNU II
- CAREX (Coordination Action for Research Activities on life in Extreme Environments)
- European Commission FP7 [ENV. 2007.2.2.1.6]
Fishes thriving in polar habitats offer many opportunities for comparative approaches to understanding protein adaptations to temperature. Notothenioidei, the dominant suborder in the Antarctic Ocean, have evolved reduction of hemoglobin concentration and multiplicity, perhaps as a consequence of temperature stability and other environmental parameters. In the icefish family, the blood pigment is absent. In contrast, similar to other acanthomorph teleosts, Arctic fish, thriving in a more complex oceanographic system, have maintained higher hemoglobin multiplicity and a highly diversified globin system in response to environmental variability and/or variations in metabolic demands. This review summarises the current knowledge on the structure, function and phylogeny of hemoglobins of fish living in polar habitats. On the basis of crystallographic analysis, a novel guideline to the interpretation of the Root effect in terms of a three-state model is suggested, implying the accessibility of an R/T intermediate quaternary structure, frequently observed in Antarctic fish hemoglobins. The occurrence of bis-histidyl and penta-coordinate states in ferric forms of polar fish hemoglobins suggests additional redox properties.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据