期刊
CURRENT PHARMACEUTICAL DESIGN
卷 20, 期 10, 页码 1499-1509出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/13816128113199990458
关键词
Blood brain barrier (BBB); brain tumor; permeability; drug efflux transport; P-glycoprotein (P-gp); breast cancer resistance protein (BCRP); chemotherapeutic agents
资金
- Natural Science and Engineering Research Council-Canada
- Manitoba Health Research Council
The delivery of many drugs to the central nervous system (CNS) is limited due to the restrictive nature of the blood-brain barrier (BBB). The reduced paracellular diffusion and the presence of various drug efflux transporters in the brain microvessel endothelial cells forming the BBB make effective treatment of brain tumors with chemotherapeutic agents particularly problematic. While P-glycoprotein (P-gp) plays an important role in limiting BBB permeability of chemotherapeutic agents, other drug efflux transporters such as breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins (MRPs) are likely to impact on chemotherapeutic levels within the brain and brain tumor. The current review examines the restrictive role that drug efflux transporters have in the delivery of chemotherapeutic agents to the brain. Consideration of different approaches taken to minimize the impact of drug efflux transporters in the BBB and improve chemotherapeutic response in treating brain tumors is also discussed.
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