期刊
CURRENT PHARMACEUTICAL DESIGN
卷 19, 期 13, 页码 2459-2473出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612811319130015
关键词
Mesenchymal stem/stromal cells; cell therapy; graft versus host disease; immunomodulatory properties; regenerative medicine; advanced therapy medicinal product; transplantation; MSCs sources
Mesenchymal stem cells (MSCs) were first isolated more than 50 years ago from the bone marrow. Currently MSCs may also be isolated from several alternative sources and they have been used in more than a hundred clinical trials worldwide to treat a wide variety of diseases. The MSCs mechanism of action is undefined and currently under investigation. For in vivo purposes MSCs must be produced in compliance with good manufacturing practices and this has stimulated research on MSCs characterization and safety. The objective of this review is to describe recent developments regarding MSCs properties, physiological effects, delivery, clinical applications and possible side effects.
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