期刊
CURRENT PHARMACEUTICAL DESIGN
卷 19, 期 40, 页码 7026-7035出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138161281940131209142843
关键词
Cocaine; methamphetamine; agonist replacement therapy; drug self-administration; clinical trial; dopamine releaser; dopamine reuptake inhibitor
资金
- National Institute on Drug Abuse [R01DA025032, R01DA021155, R01DA032254, R21DA034095]
Stimulant use disorders are an unrelenting public health concern worldwide. Agonist replacement therapy is among the most effective strategies for managing substance use disorders including nicotine and opioid dependence. The present paper reviewed clinical data from human laboratory self-administration studies and clinical trials to determine whether agonist replacement therapy is a viable strategy for managing cocaine and/or amphetamine use disorders. The extant literature suggests that agonist replacement therapy may be effective for managing stimulant use disorders, however, the clinical selection of an agonist replacement medication likely needs to be based on the pharmacological mechanism of the medication and the stimulant abused by patients. Specifically, dopamine releasers appear most effective for reducing cocaine use whereas dopamine reuptake inhibitors appear most effective for reducing amphetamine use.
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