期刊
CURRENT PHARMACEUTICAL DESIGN
卷 19, 期 4, 页码 614-623出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138161213804581954
关键词
Sirtuin modulators; cancer; drug design; epigenetics; drug discovery
资金
- Associazione Italiana per la Ricerca sul Cancro (AIRC) [6108, 6266]
- European Seventh Framework Program [256986, PANACREAS]
- University of Genova
Sirtuins are a family of NAD(+)-dependent enzymes that was proposed to control organismal life span about a decade ago. While such role of sirtuins is now debated, mounting evidence involves these enzymes in numerous physiological processes and disease conditions, including metabolism, nutritional behavior, circadian rhythm, but also inflammation and cancer. SIRT1, SIRT2, SIRT3, SIRT6, and SIRT7 have all been linked to carcinogenesis either as tumor suppressor or as cancer promoting proteins. Here, we review the biological rationale for the search of sirtuin inhibitors and activators for treating cancer and the experimental approaches to their identification.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据