期刊
CURRENT PHARMACEUTICAL DESIGN
卷 18, 期 15, 页码 2118-2134出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138161212800099955
关键词
Microbubbles; ultrasound; contrast; cavitation; drug delivery; gene therapy
资金
- UK Engineering and Physical Sciences Research Council
- Leverhulme Trust
- Royal Academy of Engineering
- University College London
- National Physical Laboratory
- Engineering and Physical Sciences Research Council [EP/G031754/1] Funding Source: researchfish
- EPSRC [EP/G031754/1] Funding Source: UKRI
Ultrasound contrast agents consisting of gas microbubbles stabilised by a polymer or surfactant coating have been in clinical use for several decades. Research into the biomedical uses of microbubbles, however, remains a highly active and growing field. This is largely due to their considerable versatility and the wide range of applications for which they have demonstrated potential benefits. In addition to contrast enhancement, diagnostic applications include: perfusion mapping and quantification and molecular imaging. In drug and gene therapy microbubbles can be used as vehicles which are inherently traceable in vivo and can provide both targeted and controlled release. In addition, the dynamic behaviour of the microbubbles in response to ultrasound excitation contributes to the therapeutic process. At low intensities microbubbles have been shown to mediate reversible enhancement of cell and endothelial permeability, including temporary opening of the blood brain barrier. At higher intensities they have been used as means of increasing the efficiency of thrombolysis, high-intensity focused ultrasound (HIFU) surgery and lithotripsy. The aim of this review is to describe the key physical principles which determine how microbubbles and ultrasound interact and the implications for their design, preparation and exploitation in diagnostic and therapeutic applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据