期刊
CURRENT PHARMACEUTICAL DESIGN
卷 18, 期 27, 页码 4126-4134出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138161212802430378
关键词
TGF-beta; natural killer; dendritic cells; CD8(+) T cells; Th1; Th2; Th17; treg cells
The capacity of the immune system to distinguish foreign from self-antigen, and to subsequently eliminate the threat of disease without injuring the host is crucial for survival. It also serves to defend against tumor formation and progression via a process termed cancer immunosurveillance. Innate and adaptive immune cell types and effector molecules collectively function as extrinsic tumor-suppressor mechanisms. However, tumors may escape immunesurveillance through a variety of mechanisms that create a local microenvironment that is unfavorable for effective tumor immunity. Transforming growth factor beta (TGF-beta) has pleiotropic effects on the immune system, and is recognized as one of the most potent immunosuppressive agents in facilitating oncogenesis. The TGF-beta pathway promotes cancer progression by concomitantly enhancing tumor metastases while inhibiting the protective host immunity. In this review, we discuss mechanisms through which TGF-beta interferes with the development of an anti-tumor immunity and potential means through which to circumvent its activity in order to define more effective cancer immunotherapies.
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