期刊
CURRENT PHARMACEUTICAL DESIGN
卷 17, 期 30, 页码 3271-3279出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138161211797904109
关键词
Stem cells; cardiovascular disease; ischemia; homing; signalling; repair
资金
- British Heart Foundation [PG/09/099]
- National Institute for Health Research Biomedical Research Unit (BRU) in Cardiovascular Medicine, Bristol UK
Although definition and mechanistic understanding of pro-angiogenic progenitor cells remains unsatisfactory, general agreement highlights their role in regenerative process following tissue injury and ischemia. Furthermore, stem-cell based therapy represents a hot topic of cardiovascular medicine. Recent studies provide new insights on the signalling pathways that modulate stem/ progenitor cell mobilization from bone marrow, homing to ischemic area and participation in vascular remodelling and tissue healing. This review focuses on current knowledge and emerging concepts on stem cell/progenitor cell trafficking in relation to changes in surrounding environment and epigenetic modifications caused by risk factors and comorbidities.
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