期刊
CURRENT PHARMACEUTICAL DESIGN
卷 17, 期 38, 页码 4308-4317出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138161211798999393
关键词
SFTI-1; inhibitor; serine proteinases; peptidomimetics; peptomers
资金
- Ministry of Science and Higher Education [ID 147819]
This work is focused on SFTI-1, a member of the Bowman-Birk family of inhibitors. This 14 amino acid cyclic peptide exhibits several features i.e. compact rigidity, well-defined structure and small size that could result in a wide range of potential applications. Some examples of engineering of the specificity of this inhibitor along with structure - activity relationships will be discussed herein. Additionally, potential uses of STFI-1 and its analogs as pharmaceutical agents will be described.
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