期刊
CURRENT PHARMACEUTICAL DESIGN
卷 16, 期 16, 页码 1826-1842出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138161210791208983
关键词
Thiazolidine; thiazolidinone; natural products; anticancer; combinatorial library approach
资金
- National Science Foundation of China [90913006]
- National Cancer Institute in U.S. [P30CA021765]
- American Lebanese Syrian Associated Charities (ALSAC)
- St. Jude Children's Research Hospital
- NATIONAL CANCER INSTITUTE [P30CA021765] Funding Source: NIH RePORTER
Nature makes many pharmacologically active compounds containing thiazolidine and thiazolidinone scaffolds. These privileged structures have been identified in many random screening assays. Molecules containing these core structures have been designed and synthesized, and they show a broad range of anticancer activities in vitro and in vivo. The combinatorial library approach has been demonstrated to be effective in lead discovery and optimization in order to improve the potency and toxicity of these compounds.
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