期刊
CURRENT PHARMACEUTICAL DESIGN
卷 15, 期 5, 页码 517-528出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138161209787315675
关键词
Fenofibrate; pleiotropic effects; inflammation; endothelial function; oxidative stress; lipoprotein-associated enzymes; cardiac remodeling; angiogenesis
Fenofibrate represents the most commonly used fibric acid derivative. The drug exerts its metabolic effects by modulating the expression of several genes involved in lipoprotein metabolism. In addition, numerous studies suggest that fenofibrate may also affect the progression of the atherosclerotic process by several lipid-independent mechanisms. This review considers the clinical pharmacology of fenofibrate and the current evidence on the pleiotropic effects of this fibric acid derivative.
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