期刊
CURRENT PHARMACEUTICAL DESIGN
卷 15, 期 27, 页码 3116-3132出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138161209789058020
关键词
-
资金
- Swedish Heart and Lung Foundation
- CMM-Soderberg foundation
- SLL/Karolinska Institutet
The inflammatory environment within the atherosclerotic lesion stimulates the 5-lipoxygenase pathway of arachidonic acid metabolism, leading to the biosynthesis of the potent lipid inflammatory mediators leukotrienes. The present review summarizes the components of this pathway; the enzymes 5-lipoxygenase (5-LO, ALOX5) with its activating protein, FLAP (ALOX5AP), LTA(4) hydrolase and LTC4 synthase, as well as the receptors for leukotriene B-4 (BLT1 and BLT2) and cysteinyl-leukotrienes (CysLT(1) and CysLT(2)), respectively. Genetic variations within the genes encoding these proteins have been associated with cardiovascular risk. Inhibiting the 5-lipoxygenase pathway through either leukotriene synthesis inhibitors or leukotriene receptor antagonists in experimental models of atherosclerosis has however generated contradictory results. Several inhibitors of the 5-lipoxygenase pathway are now evaluated in clinical trials of patients with cardiovascular disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据