期刊
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
卷 19, 期 9, 页码 708-714出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389201019666180808162011
关键词
Cytokines; inflammasome; hypertension; inflammation; preeclampsia; vascular remodeling
资金
- COST (European Cooperation in Science and Technology) [CA16225]
Background: Hypertension is a multifactorial and chronic cardiovascular condition whose complications are responsible for worldwide morbidity and mortality. An increasing body of experimental data, recognize low-grade inflammation as a basic process in hypertension onset and development since there is a strong contribution of both the innate and the adaptive immune system according to the so-called Danger-Model. In this contest, NLRP3 inflammasome represents a key signaling platform as demonstrated by its implication in several hypertension-associated conditions, such as vascular smooth muscle remodeling and proliferation. This intracellular receptor is activated by Pathogen associated molecular pattern molecules/damage-associated molecular pattern molecules signals and its mechanism of action converges on the final production of caspase-1 and, consequently, of the pro inflammatory cytokines IL-1 beta and IL-18. Objective: The aim of the present work was to point out the role of the NLRP3 inflammasome complex in the hypertensive pathology and to describe it as a new potential therapeutic target. Method: A systematic review of the literature data related to NLRP3 and hypertension correlation has been performed. Results: Numerous and well-designed experiments demonstrate that the inflammasome plays a crucial role in essential and high-salt dependent hypertension, as well as in preeclampsia, in pulmonary hypertension, and in its related secondary disorders; its mechanism includes both a central nervous and a peripheral modulation of the inflammatory pathways. To date, research is trying to design inflammasome antagonists or equivalent inhibition strategies. Conclusion: The inflammasome represents a leading promoter of hypertensive inflammation opening new perspective in the field of the clinical approach in this pathology.
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