期刊
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
卷 14, 期 5, 页码 524-536出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920101405131111104642
关键词
Neoplastic transformation; PARP inhibitors; Poly(ADP-ribosylation); Telomeres; 3-aminobenzamide
资金
- Fondazione Cariplo, Italy [2006-0734]
- Regione Lombardia, Italy (Project ATP) [13810040]
- Fondazione Cariplo
Poly(ADP-ribose) polymerases (PARPs) and poly(ADP-ribosylation) play essential roles in several biological processes, among which neoplastic transformation and telomere maintenance. In this paper, we review the poly(ADP-ribosylation) process together with the highly appealing use of PARP inhibitors for the treatment of cancer. In addition, we report our results concerning poly(ADP-ribosylation) in a cellular model system for neoplastic transformation developed in our laboratory. Here we show that PARP-1 and PARP-2 expression increases during neoplastic transformation, together with the basal levels of poly(ADP-ribosylation). Furthermore, we demonstrate a greater effect of the PARP inhibitor 3-aminobenzamide (3AB) on cellular viability in neoplastically transformed cells compared to normal fibroblasts and we show that prolonged 3AB administration to tumorigenic cells causes a decrease in telomere length. Taken together, our data support an active involvement of poly(ADP-ribosylation) in neoplastic transformation and telomere length maintenance and confirm the relevant role of poly(ADP-ribosylation) inhibition for the treatment of cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据