期刊
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
卷 13, 期 14, 页码 2632-2641出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138920101314151120122922
关键词
Tyrosine sulfation; tyrosine O-sulfation; tyrosylprotein sulfotransferase; TPST
资金
- Ministry of Education, Culture, Sports, Science and Technology
- Kurata Memorial Hitachi Science and Technology Foundation
- [18500323]
Tyrosine (Tyr) sulfation is a common posttranslational modification of secreted proteins or membrane-bound proteins that is implicated in numerous physiological and pathological processes. The Tyr sulfation modifies protein-protein interactions involved in leukocyte adhesion, homeostasis, and receptor-mediated signaling. To data, 80 Tyr-sulfated proteins have been identified. As new methodologies and bioinformatics for the detection of Tyr sulfation become available, the number of Tyr-sulfated acceptor proteins discovered is bound to increase. Further, recent advances in microscopy and fluorescence technology will provide information on the true spatial and temporal nature of Tyr-sulfated proteins within the intact cell. This review summarizes the methods for the detection of Tyr O-sulfation as well as the biological functions of sulfated Tyr. Further, illustrative examples of the impact of Tyr sulfation on the pharmacological properties are presented.
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